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High-risk additional chromosomal abnormalities at low blast counts herald death by CML

A Correction to this article was published on 10 September This article has been updated Abstract Blast crisis is one of the remaining challenges all the rage chronic myeloid leukemia CML. Whether add chromosomal abnormalities ACAs enable an earlier recognition of imminent blastic proliferation after that a timelier change of treatment is unknown. High-risk ACA at low attack counts identify end-phase CML earlier than current diagnostic systems. Mortality was lower with earlier treatment. Cytogenetic monitoring is indicated when signs of progression surface or response to therapy is disappointing. Cytogenetic abnormalities and blast increase represent the most consistent indicators of progression to end-phase CML [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ].

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